Ocular Graft Versus Host Disease
Graft-versus-host disease (GvHD) can occur following solid organ transplants or haematopoietic stem cell transplantation (HSCT) in patients with blood disorders, malignancies, immunodeficiencies or inherited metabolic diseases. Approximately 40-60% of recipients receiving allogenic HSCT from donors develop GvHD. It is a T-cell mediated process from the recipient due to tissue antigen mismatches between major or minor histocompatibility antigens. This complication can be acute or chronic in onset, affecting multiple organs and body systems including the eyes – also known as ocular graft-versus-host disease.