Infective conjunctivitis is a common ophthalmic condition encountered in general practice. Topical antibiotics are often routinely prescribed in primary care for this generally self-limiting condition, despite evidence-based guidance consistently recommending otherwise. Injudicious antimicrobial prescribing has important social, economic, and public health consequences. This review discusses the evidence-based management of infective conjunctivitis and the implications of overprescribing antibiotics for this condition in primary care.