Corneal disease and pathology is the 5th leading cause of blindness worldwide. As the cornea possesses inert immune-privilege, corneal transplantation is a highly successful way of improving clinical outcomes. The history of corneal transplantation goes back decades with the first successful human allograft and penetrating keratoplasty (PK) being performed in 1905. Since then there has been a tremendous amount of development with introduction of newer surgical techniques and instrument devices.